Studying Microglia as Possible Therapeutic Targets for Autism Spectrum Disorder (ASD) in a Mouse Model of Maternal Anti Caspr2 Antibody-Induced ASD

Abstract

Our studies use a model in which in utero exposure to maternal anti-Caspr2 antibody affects microglial maturation program, possibly arresting microglial development in male, but not female mice, leading to of Autism Spectrum Disorder (ASD)-like phenotype. We also study if we can ameliorate the ASD-like phenotype by suppressing microglial activation using an FDA approved drug.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2023
Accession Number
AD1216509

Entities

People

  • Lior Brimberg

Organizations

  • The Feinstein Institute for Medical Research

Tags

DTIC Thesaurus Topics

  • Autism
  • Biological Staining And Labeling
  • Biomedical Research
  • Boundaries
  • Cells
  • Databases
  • Department Of Defense
  • Diseases
  • Histology
  • Medical Personnel
  • Neurodevelopmental Disorders
  • Neurosciences
  • Reactivities
  • Spectra
  • Standards
  • Students
  • Trainees

Fields of Study

  • Biology

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Immunology and Pathology