SynthoPlate: Nanotechnology for Intravenous Hemostasis and Wound Healing in Prolonged Field Care

Abstract

We have created a lipid-peptide conjugate based synthetic platelet technology (SynthoPlate (trademark), US 9107845, TRL 4), that mimics the inherent platelet-mediated mechanisms of primary and secondary hemostasis in a bleeding site selective fashion, without presenting potential systemic risks. In the current project, we seek to evaluate the point-of-care hemostatic efficacy and spatio-temporally targeted wound healing treatment applicability of the SynthoPlate (trademark) nanotechnology in appropriate porcine models, with a vision to translate this technology for prolonged combat casualty care in a far forward setting. Our specific aims are: Characterization of biodistribution, systemic risks and immune response of intravenously administered SynthoPlate (trademark) in pigs; Evaluation of hemostatic efficacy of pristine SynthoPlate (trademark) and TXA-loaded SynthoPlate (trademark) in a pig model of polytrauma; and Evaluate the efficacy of SynthoPlate (trademark) alone or in combination with Gentamicin to provide wound protection and improve re-epithelialization in porcine wound models.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2023
Accession Number
AD1216829

Entities

People

  • Anirban S. Gupta
  • Matthew D Neal
  • Rodney K Chan

Organizations

  • Case Western Reserve University
  • United States Army Institute of Surgical Research
  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Analgesia
  • Blood
  • Blood Coagulation
  • Blood Coagulation Factors
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Combat Casualty Care
  • Combat Injuries
  • Dermatologic Agents
  • Health Services
  • Hemorrhagic Shock
  • Medical Personnel
  • Military Medicine
  • Organic Chemistry
  • Pharmacology

Readers

  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech