Developing Clinically Relevant Models of Mucinous Ovarian Carcinoma for Testing Therapies

Abstract

This project aims to create patient-relevant models for mucinous ovarian cancer (MOC). Over the course of the project, we have successfully developed multiple MOC and borderline tumor organoid lines able to be maintained in culture over the long term from. One of three attempts at growing 2D cell lines directly from tumor tissue were successful. Four organoid lines have also been converted to 2D cell lines (including the same one that was successful from tissue). We have tested 6 cases as PDX, some by tissue implantation but others using organoid cell suspensions, and evaluating 3 sites. None have grown at the subcutaneous site, however, both intra-peritoneal and intra-bursal routes have had some success.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2022
Accession Number
AD1216969

Entities

People

  • Kylie Gorringe

Organizations

  • Peter MacCallum Cancer Centre

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Diseases
  • Dna Sequence Analysis
  • Health Services
  • Histology
  • Intellectual Property
  • Medical Personnel
  • Neoplasms
  • Ovarian Cancer
  • Students
  • Therapy
  • Whole Genome Sequencing
  • Xenografts

Readers

  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.