Age-Associated Microglia/Macrophage Response Inhibits Remyelination
Abstract
Purpose: The purpose of this research is to evaluate whether reactive oxygen species are an age-associated inhibitor of remyelination. We will evaluate ROS deposition during remyelination, evaluate the sources of ROS, and use ROS lowering medications to evaluate how impacts remyelination Scope: We will use animal models of remyelination, microglial fate mapping, ROS measuring techniques and single cell RNA sequencing of ROS enriched cells to evaluate the source of ROS production. We will use medications to lower ROS and evaluate how ROS impacts remyelination Major findings: Currently we have conducted tissue measurements of ROS and found changes in age and time during remyelination with heightened ROS. We have also found the medication setanaxib reduces ROS after injury and boost OPC production.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1216972
Entities
People
- Jason R Plemel
Organizations
- University of Alberta