Plasmin Therapy to Prevent Post-Traumatic Heterotopic Ossification in the Upper Extremity After Severe Injury
Abstract
The purpose of this prospective animal study is to investigate new treatments to improve upper extremity joint function and prevent heterotopic ossification (HO, pathologic bone formation in muscle) follow severe injury. Plasmin is a critical reparative protease, essential for tissue regeneration following injury. The work proposed in this application will delineate the ideal timing for prophylactic plasmin therapy needed for clinical trials in both military and civilian trauma patients at risk for developing HO and associated impaired joint function. If our overarching hypothesis is proven true, the clinical impact is of most importance in the upper extremity as even partial prevention of a shoulder or elbow joint contracture can provide a wounded soldier or civilian within dependence in activities of daily living. Importantly, as we have established that plasmin is essential both for preventing HO and promoting fracture repair/bone health, this would be the first therapy that does not compromise bone biology in order to prevent HO.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2023
- Accession Number
- AD1217526
Entities
People
- John C. Reese
- Jonathan G. Schoenecker
- Stephanie G. Moore-lotridge
- Zachary Backstrom
Organizations
- Vanderbilt University Medical Center