Parameterization of a Time-Dependent Physiological Model of Combined Injury for a Locally Irradiated Superficial Thermal Burn

Abstract

Multi-test extended Fourier Amplitude Sensitivity Test (MeFAST), a global sensitivity analysis method, was applied to a time-dependent physiological model describing the local inflammatory response and early fibroblast activity triggered by a superficial thermal burn and immune cell delays and dysfunction triggered by localized radiation exposure. A reduced parameter space was then sampled and results generated reasonable parameter estimates for implementation of the model in relevant software.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2023
Accession Number
AD1217800

Entities

People

  • Amy Creel
  • Kyle Gaffney
  • Quintessa Hay

Organizations

  • Applied Research Associates (United States)

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Burns
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Computational Biology
  • Computational Science
  • Ionizing Radiation
  • Lymphocytes
  • Mathematical Models
  • Medical Personnel
  • Radiation Injuries
  • Standards
  • Statistical Tests
  • T Lymphocytes
  • Thermal Burns
  • Wound Infections

Readers

  • Approximation Theory.
  • Computational Modeling and Simulation
  • Immunology and Pathology

Technology Areas

  • Space