Acute to Chronic Pain Signatures in Traumatic Injury

Abstract

Persistent and chronic pain are significant contributors to diminished quality of life following acute musculoskeletal injury. The goal of this project is to identify critical biomarkers to predict susceptibility/resilience to the development of chronic pain after a traumatic injury. Here, we are using a population of patients with blunt chest trauma with multiple (>2) closed rib fractures, as our published prospective data indicate the chronification of pain after multiple rib fractures observed in our institution ranges from 40 to 50 percent. Biomarkers assessed include 1) prognostic clinical factors that predict a predisposition for susceptibility and/or resilience to pain chronification; 2) functional brain imaging biomarkers associated with the development of chronic pain; and 3) nociceptive genetic patterns at the time of injury that are predictive of pain chronification.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2023
Accession Number
AD1218029

Entities

People

  • Jennifer E Nyland

Organizations

  • Pennsylvania State University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • Brain
  • Burns
  • Data Analysis
  • Magnetic Resonance
  • Medical Personnel
  • Neuroimaging
  • Pain
  • Quality Of Life
  • Resilience
  • Risk
  • Statistical Analysis
  • Students
  • Thoracic Injuries
  • Thorax

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology