Concomitant Topical Treatment of Pain and Inflammation in Ocular Injuries

Abstract

Corneal injuries being exceptionally painful and debilitating, often trigger a severe inflammatory response, leading to permanent visual damage. Substance P (SP) - a neuropeptide is known for its implication in inflammation and nociception. We hypothesize that the antagonism of neurokinin -1 receptor (NK1R), SPs preferred receptor, can suppress nociception, reduce inflammation, and promote wound healing following corneal injuries. We aim to study NK1R antagonist topical treatment in two injury models: mechanical and chemical (alkali burn). In aim 1, we focus on the analgesic efficacy of NK1R antagonism and its effect on corneal nerves. In aim 2, we explore the anti-inflammatory properties of NK1R antagonism and its effect on corneal wound healing. Our findings have revealed that elevation of SP in the cornea is correlated with pain sensation in corneal injuries. Inhibiting SP receptor - NK1R helps treat ocular pain following mechanical and chemical corneal injuries.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1218031

Entities

People

  • Reza Dana

Organizations

  • Schepens Eye Research Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Burns
  • Data Science
  • Electronic Mail
  • Experimental Design
  • Eye Injuries
  • Inflammation
  • Law
  • Maryland
  • Medical Personnel
  • Pain
  • Pain Management
  • Standards
  • Students
  • Technology Transfer
  • Wound Healing

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.