Epigenetics and PD

Abstract

During Year 1, study cohort recruitment and sample processing were implemented. We collected n = 34 subjects with prodromal features of Parkinson's disease (PD) (including REM sleep behavior disorders, genetic variants in the GBA gene, and hyposmia) but without motor symptoms of PD. For each enrolled subject detailed clinical and demographic information were collected, including validated rating scales for motor and non-motor symptoms of PD and an extensive questionnaire for environmental exposure. Blood samples were collected from enrolled subjects and processed fresh for the isolation of peripheral blood mononuclear cells (PBMC) that will be utilized to extracted DNA from CD14+ monocytes for methylation analysis. Recruitment was significantly slowed down during quarter 1 and 2 by COVID-19 restrictions and limitation of personnel for sample processing. In the last quarter, recruitment dramatically increased and we have plans in place to achieve the proposed goals.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1218049

Entities

People

  • Giulietta M. Riboldi

Organizations

  • New York University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Blood
  • Cells
  • Covid-19
  • Diseases
  • Environmental Exposure
  • Exposome
  • Genetics
  • Health
  • Medical Personnel
  • Methylation
  • Monocytes
  • Parasomnias
  • Parkinson'S Disease
  • Professional Development
  • Public Health
  • Questionnaires

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Molecular and genetic basis of cancer.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.

Technology Areas

  • Biotechnology