Nonopioid Chronic Pain Treatment by Erasing Spinal Pain Memory
Abstract
This project is to rigorously evaluate if activating spinal GPR37 (G protein-coupled receptor37) has a potential of treating and preventing pain chronification by erasing spinal pain memory without posing a risk of abuse. We found that a single intrathecal (i.th.) injection of the putative GPR37 agonists TX14A and protectin D1 (PD1) erases hyperalgesic priming, a form of spinal pain memory, after an acute injury and thus prevent pain chronification upon a subsequent injury. We also found that repeated i.th. administrations of TX14A and PD1 gradually resolve chronic neuropathic pain over time while rapidly but temporarily inhibiting the pain after each injection. These results suggest that activating spinal GPR37 is a promising approach to prevent pain chronification upon recurring acute injury/pain episodes and facilitate the resolution of chronic pain with both rapid onset and long-term effects of pain relief.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1218051
Entities
People
- Jun-Ho La
Organizations
- University of Texas Medical Branch