Identifying Sociodemographic, Behavioral, and Genetic Modifiers of a Behavioral Intervention for the Prevention of Overweight/Obesity in Children with ALL
Abstract
The PEdiatric Diet intervention for children, adolescents, and young adults with ALL (PEDALL) is a 6-month, bilingual (English/Spanish), telemedicine-based intervention aimed at preventing OW/OB in C-AYA with ALL. PEDALL will recruit 708 Hispanic and Non-Hispanic C-AYA to a 6-month lifestyle behavioral counseling program aimed at improving dietary behaviors during treatment for ALL while also promoting healthy lifestyles. We propose to examine personal characteristics to first determine if they promote or hinder the efficacy of PEDALL. We will then synthesize this information to develop a risk prediction model to identify C-AYA at high risk for the development of OW/OB and who may benefit the greatest from the intervention. The study aims are to examine the modifying effect of genetic predisposition to OW/OB, defined by a trans-ethnic GPS for obesity, on the efficacy of PEDALL for the prevention of OW/OB in C-AYA undergoing treatment for ALL; identify if baseline lifestyle factors modify the efficacy of PEDALL for the prevention of OW/OB in C- AYA; examine the modifying effect of sociodemographic factors on the efficacy of PEDALL for the prevention of OW/OB in CAYA undergoing treatment for ALL; and to develop a multifactorial risk prediction models.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1218453
Entities
People
- Elena J. Ladas
Organizations
- Columbia University