Evaluating Effects in the Relationship Between Traumatic Brain Injury and Alzheimer's Disease: Epidemiological Determinants, Their Health-Related Causes, and the Resulting Disparities
Abstract
In year 3 of the project, we completed and published several analyses started in years 1 and 2. The primary deliverable of this reporting period was the analysis of the differences in risk of Alzheimer's disease following later life traumatic brain injury in veteran and civilian populations. We identified associations between incident TBI, post-TBI duration and TBI treatment intensity, with a diagnosis of clinical AD dementia in Medicare beneficiaries age 68+ from the Health and Retirement Study and found that i) later-life TBI was strongly associated with increased AD risk, especially in those requiring high-intensity/duration care, ii) effect magnitude decreased with time following TBI, iii) there are significant differences in AD risk between veterans and nonveterans, and iv) the protective effect associated with veteran status was largely due to differences in demographics, socioeconomics, and morbidity. Other published analyses extended developments of Years 1 and 2, including multivariable models for analyzing the risks and disparities in AD/ADRD, forecasting prevalence and mortality of AD using the partitioning models, and development of a new decomposition technique of disparities in life expectancy. 3rd-year analyses are at the stage of completion. Main ideas and current statuses of these analyses were presented at scientific forums and soon will be submitted for publication.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2023
- Accession Number
- AD1218456
Entities
People
- Igor Akushevich
Organizations
- Duke University