Retinal Degeneration as a Biomarker to Diagnose and Prognose Alzheimer's Disease

Abstract

The retina has gained significant attention as a potential early biomarker for diagnosing Alzheimer's Disease (AD) and monitoring disease progression. Our study aims to investigate retinal degeneration in two AD mouse models (3xtg and APPSwe) and establish correlations between retinal changes and various functional assessments, including electroretinography (ERG), optical coherence tomography (OCT), pupillary light reflex (PLR), and light aversion. The study utilizes two AD mouse lines, which mimic the pathological features observed in postmortem human AD retinas, to examine the degenerative processes occurring in the retina. By evaluating retinal degeneration in these mouse models, we aim to identify potential early biomarkers that can aid in the diagnosis and prognosis of AD.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1218463

Entities

People

  • Anna Matynia
  • Luis Perez De Sevilla Mller
  • Nicholas Brecha

Organizations

  • University of California

Tags

Fields of Study

  • Biology

Readers

  • Medical Imaging.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.