Portable NO Generation for Heparin-Free Extracorporeal Life Support in Combat Casualties
Abstract
The purpose of this project is to investigate a novel method to prevent coagulation disturbances during extracorporeal life support using nitric oxide (NO) gas. This approach will prevent local platelet aggregation and activation, eliminating the need for administration of systemic anticoagulant drugs that often cause untoward effects such as bleeding. Current NO gas delivery systems that are utilized for therapeutic inhalation of NO, such as during persistent pulmonary hypertension of newborns, are cumbersome, bulky and expensive and are certainly not feasible for out-of-hospital application during prolonged field care. For this reason, in addition to investigating NO gas in a novel application as a local anticoagulant agent during ECLS, we will investigate a novel and portable/low impact NO gas delivery system that produces NO gas from air. The overarching objective of the study is to validate this portable NO generator for mitigation of coagulation disturbances during ECLS for multiorgan support in a combat-relevant trauma model with prolonged field care and aeromedical evacuation in large animals (swine). We hypothesize that mobile NO generation enables heparin free ECLS for lung and renal failure. This work will be accomplished by comprehensive in vitro, ex vivo and in vivo experiments identifying the safety and feasibility of portable NO generation, and then exhaustive testing of the system on both the bench and in animal studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1218473
Entities
People
- Andriy I. Batchinsky
Organizations
- Geneva Foundation