Randomized Trial of Fresh Frozen Plasma Versus Albumin in Acute Burn Resuscitation
Abstract
Severe burn injury results in an inflammatory response requiring proper fluid resuscitation due to increased capillary permeability. Colloid (fresh frozen plasma [FFP] and albumin) infusion during resuscitation appears to be beneficial, however the optimal dose, duration, and timing of these fluids are unknown. Our overall goal is to determine the efficacy, safety, and microvascular effect of colloids in critically injured burn patients. We hypothesize that FFP administration in burn resuscitation is as safe as albumin and is more efficacious in both reducing the total fluid volume required and correcting burn endotheliopathy. This research study is a single-center, prospective, randomized, controlled trial in critically injured burn patients admitted to our American Burn Association (ABA)-verified burn center, directly comparing FFP and albumin. We will enroll a maximum of 100 patients with a goal of 60, and have enrolled 23 to date. 11 participants have been randomized to the FFP arm, and 12 have been randomized to the albumin arm. Preliminary results have been analyzed and found that fluid volumes administered between FFP and Albumin groups are similar in acute burn resuscitation. Endotheliopathy and glycocalyx shedding are present in both treatment groups, yet response to colloids is different. More patients are still required to have significant analysis. These results will build the foundation for safe and effective colloid resuscitation strategies in burn injury and subsequent work on freeze-dried plasma therapy in the combat setting, which is capable of revolutionizing combat burn care.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1218506
Entities
People
- Arek Wiktor
Organizations
- University of Colorado Boulder