Genome-Wide Association Study in Acquired Aplastic Anemia

Abstract

Aplastic Anemia (AA) is a previously universally fatal disease characterized by a hypocellular bone marrow and pancytopenia. AA incidence is skewed across the globe, being 2-3 fold higher in Asia than in Europe. In a variety of studies, chemical exposures and infections in different geographic areas have been described as risk factors for AA, but inconsistently, based on small sample sizes, and at prevalence too low to account for large geographic differences. Genome wide association study GWAS is a powerful research method that compiles genetic variants from many individuals to investigate the association of common genetic markers with a disease phenotype. It has led to the discovery of important new genes and associations in a number of medical conditions.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1218520

Entities

People

  • Neal Young

Organizations

  • Geneva Foundation
  • National Heart, Lung, and Blood Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Diseases
  • Genes
  • Genetic Phenomena
  • Genetics
  • Genome
  • Geographic Regions
  • Hematologic Diseases
  • Institutional Review Board
  • Local Governments
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Students
  • Training
  • United States

Readers

  • Infectious Disease/Epidemiology
  • Molecular and genetic basis of cancer.
  • Regression Analysis.

Technology Areas

  • Biotechnology