Are Tau Proteins in Blood and PET Images Related to Gulf War Illness and Risk of Comorbid Neurological Disorders?

Abstract

The primary objective of this study is to compare total tau levels and types of tau species called p-tau 181 and p-tau 217 levels in stored blood samples from Gulf War veterans. Tau levels have been associated with neurological disorders. This study has two parts: first tau markers will be analyzed in the stored blood of 300 veterans from the BBRAIN repository. Second, 30 veterans will be recruited to participate in Tau PET brain scans to see where these markers are in the brain. We will compare tau levels in healthy GW veterans to those with Gulf War Illness as well as veterans with exposures to GW exposures including pesticides, PB anti-nerve gas pills, sarin and mild traumatic brain injury.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1218529

Entities

People

  • Kimberly Sullivan

Organizations

  • Boston University

Tags

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Chemical Synthesis
  • Chemistry
  • Diseases
  • Medical Personnel
  • Nervous System
  • Neurodegeneration
  • Neurodegenerative Diseases
  • Neurosciences
  • Parkinson'S Disease
  • Persian Gulf Syndrome
  • Pesticides
  • Pharmacology
  • Toxicology

Fields of Study

  • Medicine

Readers

  • Military History / Militaries and War Studies
  • Oncology and Biomarker-Based Cancer Detection.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.