Simultaneous Multinuclear (Na+/H+) Metabolic MRI For Sodium-, pH-, and Oxygen-Sensitive Images in Human Brain Tumors

Abstract

Over the last reporting period we have (Aim 1) completed an interleaved 1H-CEST-EPI/23NaRadial FLASH imaging sequence and can collect both static and dynamic pH, O2, and sodium weighted MR information. We have enrolled 18 pre-operative patients (Aim 2) and obtained image-guided biopsies of areas thought to have high acidity, hypoxia, and sodium concentration with the goal of next correlating with tissue biology including NHE1 expression on IHC and RNA sequencing, as well as correlating with bioenergetics. Preliminary data shows a significant difference in NHE1 IHC expression in biopsy samples of high rNHE imaging contrast. Lastly (Aim 3), we have obtained pre- and post-immunotherapy pH, O2, and sodium weighted MR images in 13 patients with the goal of correlating with changes in patient outcome and tissue biology.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1219021

Entities

People

  • Benjamin M Ellingson

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Cells
  • Diseases
  • Gene Expression
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Nervous System Neoplasms
  • Oncology
  • Professional Development
  • Resistance
  • Rna Sequence Analysis
  • Stem Cells
  • Students
  • Teamwork
  • Therapy

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Molecular and genetic basis of cancer.
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech