Advancing Supersaturated Oxygen Emulsion as a Topical Treatment for Ocular Chemical Injury in Rabbits
Abstract
The purpose of the project is to examine the safety and efficacy of a novel supersaturated oxygen emulsion (SSOE) for ophthalmic use to treat acute chemical injury to the rabbit eyes. The scope of the research is: 1 Determine the ocular safety of SSOE in rabbits; 2 Determine the efficacy of SSOE in mitigating acute ocular alkali burn in rabbits. In the current reporting year (Year 1), we have accomplished the following tasks: 1) Local IACUC and ACURO approvals for animal work; 2) manufacture of the SSOE by our collaborator Coruna Medical LLC, and 3) Safety of single topical application of SSOE and vehicle in rabbits; and 4) The efficacy of SSOE in reducing ocular tissue damage in rabbits after acute burn. Single application of SSOE reduced the infiltration of inflammatory cells and stromal fibrosis in the cornea after acute alkali burn.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1219064
Entities
People
- Jia Yin
Organizations
- Schepens Eye Research Institute