A Sprayable Antimicrobial Wound Dressing for Burn Treatment in the Battlefield
Abstract
In this project, we aim to develop a sprayable, antimicrobial, and anti-inflammatory hydrogel-based wound dressing for rapid treatment of second and third degree burns in austere combat zones until an appropriate care unit can surgically treat the patient. This hydrogel includes hydrolyzed collagen (gelatin) as the bioactive base component, hyaluronic acid as the anti-inflammatory component, and peroxide microparticles as the antimicrobial component. Our sprayable hydrogel dressing will be useful in the pre-treatment of deep dermal and full thickness wounds. It will have quick and easy administration features, allow for on-site management of the burn wound rapidly, maintain a physical barrier, and be non-toxic to the tissue. The sprayable dressing can remain intact up to two weeks if necessary, it will protect the wound from mechanical effects, and prevent infection. The goals will be accomplished by pursuing the following aims: Specific Aim 1: To synthesize a sprayable antimicrobial hydrogel-based wound dressing and characterize the material properties and antimicrobial efficiency. Specific Aim 2: To evaluate the cytocompatibility of the sprayable hydrogel dressings. Specific Aim 3: To evaluate the effectiveness of the sprayable wound dressing in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1219286
Entities
People
- Gulden Camci-Unal
- Jorge Lujan-hernandez
- Mert Gezek
- Mine Altunbek
- Raymond Dunn
- Xinchen Wu
Organizations
- University of Massachusetts Lowell