Therapeutic Screening for Traumatic Optic Neuropathy

Abstract

Traumatic optic neuropathy (TON) is a blinding condition caused by trauma to the eye, head, or optic nerve. At present, the clinical standard of care is observation: there are no surgical or therapeutic interventions which have been shown to improve outcomes. We have developed a small animal model of TON and previously characterized it with electrophysiology to determine diagnostic criteria. In the present study, we use this model and electrophysiological methods to screen several candidate therapeutic approaches to TON for efficacy. To date, we have characterized partitioning of these drugs injected into the vitreous or retrobulbar space as a means for optimizing delivery.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1219293

Entities

People

  • Emma Lally
  • Eve Howard
  • Julie Racine
  • Katelyn Swindle-reilly
  • Matthew A. Reilly
  • Michelle Mosko
  • Stephanie Small

Organizations

  • Ohio State University

Tags

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Space