MUC16 Juxtamembrane Domain-Binding Peptides for Imaging and Therapy of Ovarian Cancer

Abstract

The goal of the project was the selection and identification of peptide ligands with high affinity to the MUC16 juxtamembrane domain. During ovarian cancer tumorigenesis, the MUC16 (CA-125) ectodomain is often shed leaving a short juxtamembrane (JMD) peptide protruding into the extracellular space. This epitope represents an attractive target for targeted molecular imaging and radiotherapy of ovarian cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1219341

Entities

People

  • Steven W Millward

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biochemistry
  • Molecular and genetic basis of cancer.

Technology Areas

  • Space
  • Space - Space Objects