Identification of Collateral Lethal Targets in Prostate Cancer

Abstract

Deletion of the PTEN locus, an early and frequent event in prostate cancer (PCa), invariably results in co-deletion of neighboring genes. While many of these co-deleted genes encode cell-essential functions, these cancer cells can survive dueto expression of functionally redundant paralogs elsewhere in the genome. We have established that pharmacological or genetic extinction of such sustaining paralogs results in cancer cell death while not impacting normal cells, providing a cancer specific vulnerability that we termed collateral lethality. In this proposal, collateral lethal relationships of each deleted bystander gene residing in the PTEN locus will be assessed and validated systematically. Hypothesis: We hypothesize that collateral or synthetic lethality can result from deletion of tumor suppressor loci that sustain co-deletion of neighboring genes encoding cell essential functions.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1219901

Entities

People

  • Ronald A. DePinho

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology