Identification of lncRNAs Required for Synthetic Lethal Interactions with Mutant KRAS in Pancreatic Cancer

Abstract

The major goal of this application is to identify lncRNAs involved in synthetic lethal interaction with KRAS in pancreatic cancer. There are two specific aims. The first aim is to screen for synthetic lethal interactions between lncRNAs and KRAS using the genome-wide CRISPR/Cas9-based lncRNA libraries. The second aim is functional characterization of candidate synthetic lethal lncRNAs in pancreatic cancer. The success of this study will help identify novel biomarkers and develop a better strategy for pancreatic cancer treatment. In the past year, we completed the SAM library screening and identified LINC00901 as a potential lncRNA that might be involved in synthetic lethal interaction with KRAS.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2023
Accession Number
AD1219907

Entities

People

  • Mo Yin-yuan

Organizations

  • University of Mississippi Medical Center

Tags

Fields of Study

  • Biology
  • Chemistry

Readers

  • Military Logistics and Supply Chain Management
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology