Treat Implant Loosening of Percutaneous Osseointegrated Prosthetic Limbs with Intermittent Parathyroid Hormone
Abstract
We aim to evaluate parathyroid hormone, an FDA-approved agent, as a candidate to prevent and reverse the failure of percutaneous osseointegrated prosthetic limbs (POPL) caused by implant loosening due to initial instability. We will also investigate the cellular origin and molecular mechanism of the formation of peri-implant fibrotic tissue. For this reporting period the major goals were to optimize the mouse model, to breed Lepr-creER mice, and to confirm that Lepr positive cells conditionally induced in this mouse line can mark the fibroblasts. We successfully bred these mice and confirmed that Lepr positive cells are the cellular origin of the fibrosis. We have tested various implants to improve the reproducibility of this mouse model. We demonstrated that mechanical loading is necessary for the formation of both bone and fibrosis in this model. To carry out the project as proposed we will need to develop an automated loading device and implants that can be attached to it.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1219928
Entities
People
- Xu Yang
Organizations
- Hospital for Special Surgery