Persistent Resting-State fMRI Hyperconnectivity as a Risk Factor for Alzheimer's Disease After TBI
Abstract
The overall hypothesis to be investigated is that Abeta associated paroxysmal hyperconnectivity episodes thought to represent the task free fMRI equivalent of paroxysmal network hypersynchrony play a decisive role in the progression from preclinical to clinical AD. A critical role for network hypersynchrony could also explain why TBI is a risk factor for the development of AD in later life since impaired Abeta clearance and permanently altered neuronal excitability favoring paroxysmal network hypersynchrony have shown to be features of the chronic stage of TBI. Patients with a history of TBI whose task-free fMRI shows paroxysmal hyperconnectivity episodes are therefore expected to have a higher risk to develop AD in later life, i.e., havehigher Abeta plaque loads and worse cognitive abilities, than those who do not show this abnormality. The project will use completely de-identified longitudinal imaging and clinical data from the DoD ADNI data repository to address these questions.Year 4 was spent 1. On investigating how the gray matter/tau load pattern identified in the previous reporting period influence gray matter loss over time. 2. Identification of the hypothesized hyperconnectivity state and its relationship to amyloid and tau load as well as disease state (TBI, PTSD) gray volume loss.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1219934
Entities
People
- Susanne G Mueller
Organizations
- University of California, San Francisco