Muscarinic 3 Receptor in Pancreatitis Pathogenesis and Therapy

Abstract

The proposed research project addressed the topic area of pancreatitis. The main goal was to determine whether hyper-activation of the M3 acetylcholine receptor located on pancreatic acinar cells induces pancreatitis. We studied this through premature intra-acinar cell trypsinogen activation and measuring increased pro-inflammatory NF-kB pathway signaling as well as by targeting the muscarinic 3 receptor with an FDA approved chemical antagonist Darifenacin. Additionally, we also studied commercially available human pancreatic acinar cells to see if they respond similarly to our mouse studies.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2023
Accession Number
AD1220542

Entities

People

  • Baoan Ji

Organizations

  • Mayo Clinic

Tags

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology and Pathology
  • Molecular and Cellular Biochemistry