Supersaturated Oxygen Emulsion as a Novel Topical Treatment for Ocular Chemical Injury
Abstract
The purpose of the project is to develop a novel supersaturated oxygen emulsion (SSOE) for ophthalmic use to treat acute chemical injury to the eye. The major goals are: 1) Manufacture, optimize, and characterize SSOE for ocular application; 2) Determine the safety and efficacy of immediate SSOE application in mitigating acute ocular burn in vivo in mice; and 3) Determine the efficacy of delayed SSOE application in preventing tissue damage and promoting tissue repair after ocular burn in vivo in mice. We have previously completed Major Tasks 1-3 in Years 1-2: 1. Engineering and characterization of SSOE for tunable oxygen delivery; 2. Determine the safety, biocompatibility and toxicity of SSOE in vitro and in vivo; and 3. Determine the efficacy of SSOE in reducing ocular tissue damage after acute burn. In the current (Year 3) reporting period, we completed Major Tasks 4-5: 4. Determine the mechanisms by which SSOE preserves tissue integrity after acute burn; and 5. Determine therapeutic window of effective SSOE treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1220546
Entities
People
- Jia Yin
Organizations
- Schepens Eye Research Institute