Programing Biomolecular Nanodevices For Targeted Immune Cell Recognition and Payload Delivery
Abstract
The major goal of this project is to lay the groundwork for developing next-generation therapeutic devices using biologically inspired nanotechnology. Our vision is to create, de novo, nanoscale devices from DNA,RNA, and proteins that rival the power and sophistication of natural machinery found in living organisms. Such devices, if realized, would enable a variety of life-saving and life-improving technologies that seem feasible based on first principles and physical laws, but are unprecedented in humans. Examples include safely activating and retargeting immune cells to attack and clear specific cell types (e.g. cancer cells) that otherwise evade the immune system, or safely suppressing the immune system to avoid host rejection of a transplanted organ. Longer-term applications of our nanostructures could include nanoscale scaffolding and stem-cell stimulation for limb regeneration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 05, 2023
- Accession Number
- AD1220581
Entities
People
- Shawn M Douglas
Organizations
- University of California, San Francisco