Portable Diffuse Optical Sensors for Point-of-Care Monitoring in Prolonged Field Care
Abstract
The main purpose is to develop the prototype of a portable diffuse correlation spectroscopy (DCS) and near infrared spectroscopy (NIRS) based optical system with multiple capabilities to monitor tissue blood flow, blood volume and oxygenation. The proposed system includes multi-distance multi-wavelength NIRS-based sensors and DCS-based optical fibers. The proof of concept and system test studies include design and study of phantom and animal models, tests in hemorrhage assessment during pre-shock, shock, after fluid resuscitation, and during hypoxia and edema development. Final proof of concept study will be conducted using a real-life clinical scenario with adult pig model (uncontrolled hemorrhagic shock). A fully operational DCS optical system with all the components including the sensor array, data acquisition box and software was developed in Year 1. The novel head phantoms and dynamic microvasculature model (mimicking adult human head with extracerebral layers) were also designed and implemented to model varying cerebral blood volume and cerebral blood flow in Year 2. In Years 2 and 3, animal models and test plans were developed and conducted for detection of graded hemorrhage, hemorrhagic and hypoxic shock. The results validate that the prototype system is capable of measuring microvascular blood flow rate, volume and oxygenation changes in response to various type of brain injuries.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1220611
Entities
People
- Kurtuluş İzzetoǧlu
Organizations
- Drexel University