Novel Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA-A Multicenter RCT
Abstract
: Infection after treatment of high-energy military fractures is very common and continues to cause significant morbidity. Recently, a study showing the useof local vancomycin powder around metal hardware used to treat these at-risk fractures results in a reduced risk of infection. The powder is thought to create a kill zonearound the metal, prevent bacterial colonization, and therefore reduce the rate of postoperative infection. Specific Aims: Our primary specific aim is to demonstrate thatthe infection rate (defined by CDC criteria) is lower in patients with at-risk fractures treated with standard of care as well as local vancomycin and tobramycin thanpatients treated with standard of care and vancomycin alone. Additional specific aims include investigation of the potential development of antibiotic resistance andexamining bacterial sensitivities in patients who become infected in the treatment group and comparing the proportion of additional complications such as wounddehiscence and nonunion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1220631
Entities
People
- Robert V. O'toole
Organizations
- University of Maryland, Baltimore