Nanoparticle Controlled Steroid Release From Endotracheal Tubes to Mitigate Airway Inflammation During Aeromedical Evacuation
Abstract
Novel, field deployable advanced airway devices to secure the airway following airway inhalation injury in prolonged field care and multidomain operations are lacking. Traditional endotracheal intubation, frequently with large diameter endotracheal tubes, puts these individuals at risk for posterior glottic stenosis, tracheal stenosis, and long-term voice, swallowing, and airway complications. No current mitigating technologies allow for airway maintenance and reduced mucosal injury and local drug delivery. This project aims to employ a polymer-mesh coated endotracheal tube platform able to directly deliver corticosteroid to the laryngotracheal complex via sold state diffusion. We hypothesize that continuous delivery of corticosteroids will lead to improve local wound healing, resulting in more native biomechanical tissue properties and decreased fibrosis and stenosis. Dexamethasone-loaded polymer mesh was electrospun onto ETTs trimmed to transglottic endolaryngeal stents and secured in 18 Yorkshire Crossbreed swine with directed 150C inhalation burns. Native trimmed ETTs were implanted in 18 additional swine with identical inhalation burns. Both groups were observed for varying lengths of time. VF stiffness after burn decreased with longer intubation. Stiffness similarly decreased with local dexamethasone delivery, and VF stiffness in the continuous dexamethasone delivery group was increased compared to tissues without local dexamethasone. These results correlated with histologic findings. Collectively, these data support the hypothesis that local dexamethasone delivery increases VF stiffness compared to native ETTs in a laryngeal burn model, bringing tissue stiffness closer to native tissue biomechanics. These data suggest continuous local dexamethasone delivery via drug eluting ETTs may help reduce laryngotracheal scarring with laryngotracheal burn.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2023
- Accession Number
- AD1220682
Entities
People
- Diana Del Monaco
- Gabriela Gonzales
- Gregory R Dion
- Ronit Malka
- Stephanie Hinkley
- Teja Guda