Pilot Study of Role of Continuous Tissue pH Measurement in the Diagnosis of Acute Compartment Syndrome
Abstract
Objective: Demonstrate that continuous measurement of tissue pH (cIMpH) shows worsening values suggesting progressive acidosis in the injured limb, to correlate those data with the results of both detailed serial clinical assessments and continuous pressure monitoring data collected for the parent study, and to compare tissue pH in patients receiving TUF versus standard of care. Study Design: Observational study of 40 patients enrolled in a larger trial of patients with severe lower leg injuries at high-risk of ACS. Enrolled patients will receive cIMpH measurements in both legs, as well as the procedures mandated by the parent study (detailed serial clinical assessments, cIMP monitoring in the injured leg, and continuous TUF for patients randomized to the experimental arm of the parent study). Military Benefit/Clinical Impact: This proposal validates methods to diagnose and manage ACS that is ideally suited to care of the injured soldier in a prolonged field care scenario. The addition of cIMpH measurement in a subset of patients in the parent study will supply pilot data regarding efficacy of IMpH as a simple biomarker indicating whether tissue perfusion is adequate or becoming compromised, and that can be readily measured in in austere environments and continued during medical evacuation and early patient resuscitation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1221140
Entities
People
- Andrew H. Schmidt
Organizations
- Hennepin Healthcare Research Institute