Treatment and Response Targets for Helicobacter-Associated Gastric Cancer
Abstract
The project deals with identifying treatment and response targets for Helicobacter-associated gastric cancer. The purpose is to discover novel druggable targets by testing efficacy of approved compounds. An additional purpose is to identify immune related genes as predictors of treatment response. To accomplish the goals of our project we are using fresh gastric tumor tissue samples harvested from patients undergoing gastrectomy to generate patient derived xenograft (PDX) and patient-derived orthotopic xenograft (PDOX) models. In addition, the work makes use of gastric cancer patient samples stored at our UCSDs Moores Cancer Center Biorepository core. We have successfully established a gastric cancer PDX model and show that tumor gastric tissues in the PDX model express the same genes as in the original tumor. We have started drug targeting studies by testing efficacy of approved compounds as promising candidates for gastric cancer treatment. Figure 1 (below) shows targeting of a protein from a differentially expressed gene (DEG) that exhibited overexpression in our accelerated model (Fig. 2A) and was similarly elevated in human gastric cancer biopsies (Fig. 2B) - proteasome subunit beta type 8 (PSMB8).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2023
- Accession Number
- AD1221786
Entities
People
- Marygorret Obonyo
Organizations
- University of California, San Diego