Repair of the Traumatically Injured Central Visual System by Interneuron Transplantation
Abstract
In the second year of the award, we performed a comprehensive analysis of the anatomical and electrophysiological incorporation of MGE cells into brain injured V1 circuits. These studies will be presented as an abstract at SfN this year (Hou, et al., 2023) and show encouraging results for the further development of this cell therapy for central visual system injury. We completed an anatomical analysis of the grafted cells. We discovered deficits in synaptic inhibition following TBI to V1, and inhibitory drive to V1 neurons was restored by MGE cell grafts. We performed initial behavioral and in vivo electrophysiological analysis of V1 in control and brain injured animal with and without MGE cell grafts. During the next year, we plan to complete the proposed anatomical, electrophysiological and behavioral studies testing the therapeutic efficacy of interneuron cell transplantation for V1 TBI. This work will provide new information about the plasticity of the injured visual system and advance our long-term goal of developing an interneuron cell therapy for TBI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1221790
Entities
People
- Amir Alizadeh
- Bowen Hou
- David Lyon
- Jisu Eom
- Robert F Hunt
Organizations
- University of California, Irvine