Genomic and Biological Risk Prediction of Aggressive and Lethal Prostate Cancer in African American Men
Abstract
Despite robust and consistent evidence showing African-American men have poorer prostate cancer-specific outcomes, risk stratification tools (based on prostate-specific antigen, Gleason score, and tumor stage) are not currently able to incorporate racial disparities in a clinically meaningful way and identifying which men are at an increased risk of lethal prostate cancer remains a major challenge to the field. To this end, the purpose of this project is to develop a novel genomic/biological risk prediction approach to prostate cancer in men of African descent by identifying and developing a genomic signature/risk classifier that is predictive of aggressive and potentially lethal prostate cancer. The resulting genomic/biological signature could identify African-descent men most likely to be at risk of lethal prostate cancer. We proposed to do this by: Aim 1: Identify and validate scenarios where current prostate cancer risk assessment tools are least prognostic in African-American men. Aim 2: Identify and characterize the prostate cancer genomic risk profile in African-descentmen compared with European-descent men, particularly in clinical scenarios identified.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2023
- Accession Number
- AD1221795
Entities
People
- Brandon A Mahal
Organizations
- University of Miami