A Novel M2 Lipogenic Macrophages Associated with Fracture Callus Are Altered in Type 2 Diabetes
Abstract
Type II diabetes (T2DM) is usually viewed as a systemic disease where there is insulin resistance accompanied by increased glucogenesis by the liver leading to increased systemic glucose levels. However, much evidence suggests that in T2DM there is also chronic proinflammation with an increase in M1 proinflammatory macrophages. Little is known about how these changes in macrophage phenotype contribute to the disease phenotype. The findings from the research presented in this proposal will have a large impact in the PRMRP topic areas of diabetes and prevention of complications. Specifically, this proposal aims to understand the mechanisms surrounding the diabetic complication of impaired wound healing. Ideally, this work will result in a therapeutic to treat this complication. In addition, the findings from these studies may also allow for the identification of novel and unique biomarkers. It is hypothesized that the novel macrophages described in this application may be altered in diabetic wound healing and these cellular and metabolic responses may serve as novel and unique biomarkers for the disorder. These metabolic or functional differences may also allow for the characterization of disease progression as these cellular populations are uncharacterized in pre-diabetic and diabetic molecular environments. Key differences in these macrophages may also reveal potential molecular changes eliciting the heterogeneity in the disease complications.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2023
- Accession Number
- AD1221798
Entities
People
- Alan R Davis
- Elizabeth A. Olmsted-Davis
Organizations
- Houston Methodist Research Institute