TBI Exosomal Activity in Military Personnel: Perivascular Space and Role of Indicators of Sleep Metrics TEAM PRISM

Abstract

Objective: Determine if proteins in the blood are related to chronic neurological symptoms, poor sleep, and possibly neuroimaging differences after a traumatic brain injury (TBI). Study Design: We will use already collected clinical data, polysomnograms (PSG) sleep studies, imaging data, neuropsychological tests, and blood samples from service members with at least one TBI (n=300) and without any TBI (n=50) from an ongoing study at the National Intrepid Center of Excellence (NICoE) in SMs. We will use our developed methods to isolate brain-specific exosomes and examine their contents. We will also measure circulating blood concentrations of neuronal, brain barrier function, inflammation, and clearance-related proteins.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1221821

Entities

People

  • Jessica Gill

Organizations

  • Johns Hopkins University

Tags

Fields of Study

  • Medicine

Readers

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  • Oncology and Biomarker-Based Cancer Detection.
  • Rehabilitation and Prosthetic Care for Military Service Members and Veterans with Limb Loss or Disability.

Technology Areas

  • Space