An Assessment of the Effects of Pressure Infusion with the Novel LifeFlow Device on Blood
Abstract
The novel LifeFlow device, was developed by 410 Medical, as a non-battery-operated method for rapid infusion of crystalloid and blood products. Hemorrhage is the leading cause of potentially survivable death on the battlefield. Early infusion of blood products prehospital has been shown to reduce mortality. The current standard for infusion prehospital is the use of a pressure bag or gravity. Pressure bags are limited because the pressure applied decreases as the bag empties. The LifeFlow uses a pull-push method in a hand squeeze device. Preliminary data demonstrates substantially faster infusion rates that are sustained over the entire bag of crystalloid. Currently, there is no data assessing the use of this device by medics who would be the primary end-user in a prolonged field care (PFC) setting. It remains unclear whether this device has an acceptable range of effects on blood after rapid infusion through the LifeFlow versus the currently used pressure bag system. We are yoking this effort to an approved study so no new animals will be required to support this effort. In this effort, we will assess for hemolysis and other measures of blood cell damage using this device compared to a pressure bag system in a large animal model. This protocol will be attached to Emergency skills training using the pig (sus scrofa) model (FWH20190004AT) protocol in order to obtain the units of blood necessary to complete the study. A member of the study team will obtain 2 units of blood into standardized blood collection bags. We will aim to collect 1-2 units of blood per pig; to meet our goal of 40 units of blood total we will use anywhere between 20-40 pigs. We will use either peripheral access or central venous access for capture of the blood into the bag. Both procedures are standard procedures that are described in Emergency skills training using the pig (sus scrofa) model (FWH20190004AT) protocol.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 13, 2023
- Accession Number
- AD1221885
Entities
People
- Dayana Sifuentes
- Fabiola Mancha
- Jessica Mendez
- Joseph K Maddry
- Melody Martinez
- Steven G Schauer