Comparison on Porosity, Hardness, and Indentation Modulus of 3D Electrospun PCL Scaffolds, OsteoGen, and Bio-Oss Collagen for Alveolar Ridge Preservation
Abstract
Socket grafting is an effective procedure to preserve the alveolar ridge post-extraction, reducing the loss of horizontal and vertical dimensions. This study evaluated the mechanical properties of three electrospun PCL scaffolds (e.g., PCL only, PCL-collagen, and PCL-collagen-hydroxyapatite) and compared them with two commercially available socket grafting materials: OsteoGen Plug (Impladent) and Bio-Oss Collagen (Geistlich Pharma). A spherical copper mesh was used as a collector to prepare the 3-D PCL scaffolds by electrospinning. The scaffolds were then functionalized with collagen and mineralized with hydroxyapatite (HA). Micro-CT was used to measure scaffold porosity and internal structures. The modulus and hardness of the electrospun scaffolds and grafting materials were characterized by nanoindentation. For each group, a mean and standard deviation (SD) was calculated for modulus, hardness, and porosity. Significant differences were determined using one-way analysis of variance (ANOVA) testing and Turkey's post hoc test. The porosity of the PCL scaffolds (56.85 - 61.51 percent) were comparable to Bio-Oss Collagen (52.22 percent) but less than OsteoGen (97.16 percent). The hardness and indentation moduli were comparable to OsteoGen and the spongy aspect of Bio-Oss Collagen. This may translate to PCL scaffolds having similar clinical handling properties to OsteoGen and cellular response similar to Bio-Oss Collagen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 28, 2023
- Accession Number
- AD1222423
Entities
People
- Loc V. Tran
Organizations
- Uniformed Services University of the Health Sciences