Human Laser Retinal Dose-Response Model, Version 2
Abstract
A generalized human dose-response model for retinal injuries provides improved fidelity for risk assessment. Such a dose-response model requires two parameters a mean effective dose and a standard deviation. A separate publication addresses the latter and accounts for human variability. This publication presents a new generalized model for the mean effective dose. It has only two wavelength-dependent parameters, an inflection exposure duration and a short-pulse damage threshold, which fit experimental non-human primate injury data. The model includes an estimate of the factor to convert to human exposure. Use of the dose-response parameter models (mean and standard deviation) for calculating a probability of injury is detailed and illustrated. This version of the model for the mean uses a simplified model for the standard deviation. These models capture the essential physical features involved in retinal laser exposures, but further refinements are anticipated as additional experimental and numerical simulation results become available.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 12, 2023
- Accession Number
- AD1222469
Entities
People
- Chad A. Oian
- Edward A. Early
- Elharith Ahmed
- Robert J. Thomas
- Semih S. Kumru
Organizations
- Air Force Research Laboratory