Design of Protein Biomaterials through Tailored Shape and Packing Strategies of Patchy Particles
Abstract
The overarching goal of the current grant was to develop generalizable design principles for protein assembly and determine how to program simple proteins to self-assemble into higher order structures different from those they might ordinarily form in the absence of programming. Charge complementarity through supercharging is the main route to programmability we proposed to explore because excess charges can be placed in designated places along the protein to promote associations that might differ from those of the original (un-supercharged) protein. However, it is not the only route, as other methods of engineering non-native interprotein associations are possible today through the judicious placement of interaction patches relying on other forces, such as van der Waals attraction, along the proteins. The grant identified the following major goals: 1. Extending hierarchical assembly 2. Generalization to other proteins 3. Hierarchical assembly of protein complexes for materials production.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2022
- Accession Number
- AD1223012
Entities
People
- Sharon Glotzer
Organizations
- University of Michigan