Diabetes Subtypes and Lethal Prostate Cancer Across Puerto Rican, African American, and Non-Hispanic White Veterans
Abstract
Puerto Rico (PR) residents have a higher prostate cancer (PCa) mortality than non-Hispanic White (NHW) or Hispanic men living in the continental U.S. Indeed, PCa mortality among PR men is second only to Black men. Our over-arching hypothesis is that severe diabetes in the presence of obesity will alter the prostate tumor microenvironment leading to a poorer PCa prognosis. Specific Aim 1 is to determine whether there is an interaction between diabetes and obesity leading to the diagnosis of lethal PCa, and whether this interaction differs by race/ethnicity. We will develop a cohort of over 4,000 prostate biopsy patients from the Durham VAMC (54 percent Black, 46 percent NHW) and over 3,500 biopsy patients from the San Juan VAMC. Specific Aim 2 is to determine if there are differences in prostate tissue gene expression among PR, Black, and NHW PCa patients with diabetes, and with and without obesity. Analysis includes 225 diabetics diagnosed with PCa, including 75 Black and 75 NHW patients recruited from the Durham VAMC, and 75 diabetic PCa patients recruited from the San Juan VAMC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1223112
Entities
People
- Jay Fowke
Organizations
- University of Tennessee