In Vivo Imaging of Fibrin Deposition and Its Correlates in Multiple Sclerosis
Abstract
Our study proposes to translate a novel fibrin-specific molecular imaging approach based on 64Cu-FBP8 brain positron emission tomography (PET), developed by investigators at Massachusetts General Hospital for detecting in vivo fibrin deposition in brain of patients with relapsing-remitting multiple sclerosis (RRMS). The overall hypothesis is that, using this method, we will be able to non-invasively measure in vivo persistent, deposition of fibrin in the brain of people with RRMS including both the white matter (WM) and the gray matter (GM), where it will be closely associated with the presence of local structural damage. Our initial data show in RRMS, relative to a control population, an increase in 64Cu-FBP8 PET signal that is particularly evident in acute WM lesions, but also present in the normal appearing WM and cortex. Specifically, fibrin deposition as measured by 64Cu-FBP8 uptake can be detected in patients at the site of the acute brain WM plaque that shows contrast enhancement on post-gadolinium MRI scans. We found that in these areas 64Cu-FBP8 uptake persisted at late timepoints following the radiotracer injection, indicating that the abnormal 64Cu-FBP8 uptake reflects local brain deposition of fibrin and not simply increased brain delivery of the tracer due to blood-brain barrier disruption.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1223141
Entities
People
- Mainero Caterina
Organizations
- Massachusetts General Hospital