Therapeutic Function of Glucagonlike Peptide-1 (GLP-1) for Hearing Restoration After Blast Exposure or Traumatic Brain Injury (TBI)
Abstract
The objective of this project is to investigate the potential therapeutic function of Liraglutide (glucagon-like peptide-1 receptor (GLP-1R)) to mitigate the auditory injury after blast exposure in animal model of chinchilla. There are two aims: Aim 1. Identify the therapeutics of liraglutide in ameliorating auditory injuries in both pre- and post-blast treatments in relation to the blast overpressure (BOP) level or TBI severity over different time courses. Aim 2. Investigate the beneficial effects of liraglutide on the mitigation of the central auditory damage following repetitive exposures to the low BOP (G1) or mild TBI (G2). Accomplishments in Year 4 include: 1) hearing function tests in drug treated chinchillas at G2 BOP level of 15-25 psi for 3 blasts on Day 1 with both ears open (without protection) and in animals with additional 3 blasts on Day 4 over two time courses: 14 and 28 days; 2) summarizing of the completed experiments on therapeutic function of liraglutide for mitigation of blast-induced auditory injury in relation to the BOP level, hearing protection condition, and recovery time course; 3) immunofluorescence imaging and analysis of chinchilla brain tissues from all drug-treated groups and blast control groups (open and protected). Results demonstrate that the blast intensity and repeated blats affect the therapeutic function of liraglutide on mitigation of hearing damage in ears with and without protection and further study is needed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2023
- Accession Number
- AD1223403
Entities
People
- Rong Gan
Organizations
- University of Oklahoma