Antibiotic-Induced Dysbiosis Promotes Lung Metastasis

Abstract

Recent studies by various groups have revealed that antibiotics (ABX)-induced dysbiosis has systemic consequences including changes in vasculature beds at distal sites, and ultimately acceleration of lung carcinogenesis. These observations and their clinical implications motivated us to investigate whether dysbiosis also has an influence on lung metastasis. The long-term goal of our work is to define the systemic effects of ABX induced dysbiosis, to develop strategies to quell metastasis. The overall objective of this proposal is to determine the influence of ABX on lung metastasis progression and dissemination. Attaining this objective will be a major step in understanding the processes of lung metastasis and off-target effects of ABX. In this concept award, we test our central hypothesis is that ABX-induced dysbiosis increases fibronectin in the perivasculature stroma, creating a favorable pre-metastatic niche.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2023
Accession Number
AD1223410

Entities

People

  • Ruud Dings

Organizations

  • University of Arkansas for Medical Sciences

Tags

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
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  • Oncology (Cancer Research).