Portable Quantum Dot Electroluminescent (QDEL) Light Sources for Point of Care Photodynamic Treatment of Deep Wound MDR Infections
Abstract
The primary objectives of our STTR Phase I project were to develop reliable, flexible, and lightweight quantum dot electroluminescent (QDEL) light sources, and to demonstrate the effectiveness of these portable QDEL devices in treating multidrug-resistant (MDR) bacteria through in-vitro antimicrobial photodynamic therapy (aPDT) studies. Our previous work with rigid on-glass QDEL devices has shown their efficacy in destroying MDR pathogens, outperforming antibiotics. However, while flexible QDEL (fQDEL) devices have been fabricated, their reliability and performance were not yet on par with rigid devices, limiting their application as an aPDT light source. To determine the feasibility of using portable QDEL light sources for point-of-care aPDT applications, our Phase 1 project aimed to answer two technical questions: 1) Can lightweight fQDEL devices achieve similar reliability, efficiency, and optical power density (OPD) performance as their rigid counterparts through the engineering of polymer substrate and barriers? 2) Can fQDEL device-based aPDT demonstrate bactericidal effects in-vitro, and achieve high efficacy against both gram-positive (G+) and gram-negative (G-) MDR pathogens without inducing drug resistance?
Document Details
- Document Type
- Technical Report
- Publication Date
- May 16, 2023
- Accession Number
- AD1223613
Entities
People
- Raymond Lanzafame