The Effects of PEGylated Metal-Organic Frameworks for pH-Responsive Drug Delivery
Abstract
Metal-organic frameworks (MOFs) represent a novel class of hybrid porous nanomaterials that contains high surface modifiable abilities, strengthened drug encapsulation capacities, and improved biocompatibilities for treating resistant cancers. The versatile surface functionality of MOFs enhances the carrier stability to protect the drug from degradation and allows specific distribution of the drug at desired locations. In this work, three zirconium-based MOFs (UiO-66, MOF-808, NU-1000) were incorporated with polyethylene glycol (PEG) chains through click modulation to optimize the drug release efficacy by preventing lysosomal degradation under pH 7.4 and generating a pH-responsive cargo release at pH 5.5, which is the pH that is relatively close to the cancer cell environment. The PEG chains can provide a hydrophilic protective barrier on MOFs to prevent their rapid degradation under pH 7.4 (healthy cell environment). As the pH becomes more acidic, the PEG can depolymerize and the MOF ligands can dissociate to degrade the MOFs to further release the encapsulated drug. This unique design endows the PEGylated MOFs with pH-responsive properties and targeted drug delivery capability. In this study, both uncoated and PEG-coated MOFs with diverse structures were investigated to examine the effects of PEGylation on drug delivery.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 19, 2022
- Accession Number
- AD1223848
Entities
People
- Suki S. Liang
Organizations
- California State University, Los Angeles