A 6-month Evaluation of Novel Antibiotic Bonded Prosthetic Graft Patency in the Setting of a Polymicrobial Infection in Swine (Sus scrofa)
Abstract
This study was a unique in-vivo study that examined the long-term ability of novel antibiotic grafts to resist infection and maintain patency. A 6-month survival model with 5 proposed groups that included sham, a positive control group ePTFE, a positive control group for Dacron, experimental group bonded with ePTFE, and an experimental group bonded with Dacron was developed with technical and veterinary staff; the longest survival model our group has used to date. Due to unforeseen technical issues with animal growth, a number of amendments were necessary yielding an overall decreased number of total animals enrolled. A decision was made to remove the positive control Dacron group and experimental group bonded with Dacron. With such low number of test animals, a definitive comparison of groups could not be reached. However, none of the test animals with antibiotic-bonded vascular grafts (ePTFE) revealed infectious changes or showed evidence of rejection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 10, 2019
- Accession Number
- AD1223885
Entities
People
- Brandon W. Propper
- Jennifer Cox
- Kai W. Hata
- Mamie Stuff
- Michael Clemens
- Shaun M. Gifford
- Zachary M. Arthurs
Organizations
- 59th Medical Wing