DNA-Based Technologies for Reading and Writing Large-Scale Molecular Patterns with Nanoscale-Precision
Abstract
In many technologies there is a trend toward simultaneous miniaturization and increased capacity. The amount of data stored on consumer-advertised desktop computer hard drive, for example, has increased exponentially from 0.1 GB in 1980 to 1000GB in 2010 while occupying the same volume. In data storage, the benefits scale only linearly with the amount of data fitting in a given volume, but nevertheless there is a strong driving force for development; computer data is currently generated and stored at 10^12 GB zettabytes) per year worldwide. In other classes of problems, such as biology, benefits appear to increase out of proportion to scaling. For example, the success of animals requires functionality from nanometer-scale enzymes, molecular motors, and selective membrane pores through the meter-scale processes of digestion, nerve conduction, and musculoskeletal mobility. Nature occasionally sees competitive advantages in extending the upper limit of the scale to tens of meters. A fundamental goal in science and engineering, therefore, is to maintain nanometer-scale (molecular) control of matter across length scales of 1 um (1,000-fold range,), 1 mm (1,000,000-fold), or even higher; ar d a fundamental challenge in biological research is to understand and measure the nanoscale effects of individual biomolecules across large spatial scales.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 12, 2022
- Accession Number
- AD1224096
Entities
People
- Peng Yin
Organizations
- Harvard College